Leptin-induced weight loss is not solely mediated by anorexia
نویسندگان
چکیده
منابع مشابه
Leptin-induced weight loss is not solely mediated by anorexia.
The discovery of the ob-gene product leptin in 1994 (1 –2) and the subsequent identification of grossly obese children lacking leptin (3) or its receptor (4) considerably increased the expectation of finding an effective cure for grossly obese humans. Very soon after its discovery it became evident, however, that a deficiency of leptin did not account for obesity in the large majority of patien...
متن کاملMyD88 is a key mediator of anorexia, but not weight loss, induced by lipopolysaccharide and interleukin-1 beta.
Systemic inflammatory signals can disrupt the physiological regulation of energy balance, causing anorexia and weight loss. In the current studies, we investigated whether MyD88, the primary, but not exclusive, intracellular signal transduction pathway for Toll-like receptor 4 and IL-1 receptor I, is necessary for anorexia and weight loss to occur in response to stimuli that activate these key ...
متن کاملAmylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction‐induced weight loss in rats
OBJECTIVE Co-administration of amylin and leptin induces synergistic and clinically meaningful (>10%) weight loss that is attenuated as the degree of obesity increases. We explored whether calorie restriction (CR) could restore amylin/leptin synergy in very obese rats. METHODS Sprague Dawley rats on high-fat diet (696 ± 8 g, n = 72) were randomized to three cohorts (C1-C3). Rats in C1 were ad...
متن کاملChanges in the gastric ghrelin concentration after whole-abdominal irradiation in rats: Is this related to the radiation-induced anorexia and weight loss?
Background: Ghrelin is a hormone related to food intake in rodents and humans, mainly produced in stomach. This study aimed to determine the effect of irradiation on ghrelin concentration in the gastric mucosa of rats. Materials and Methods : Twenty-five rats were exposed to 15 Gy of whole-abdominal irradiation. Gastric tissue samples were obtained 1, 3, 7, 30, and 90 days after irradiation. Fi...
متن کاملLeptin produces anorexia and weight loss without inducing an acute phase response or protein wasting.
The ob gene product leptin is known to produce anorexia and loss of body fat when chronically administered to both lean and genetically obese mice. The current study was undertaken to examine whether administration of recombinant leptin in quantities sufficient to produce decreases in food intake and body weight and alterations in body composition would elicit either an hepatic acute phase prot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2003
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1480011